31643-49-9, A common heterocyclic compound, 31643-49-9, name is 4-Nitrophthalonitrile, molecular formula is C8H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 4-nitrophthalonitrile (1) (2 g, 11.5 mmol) was dissolved in dry DMSO (20 mL) and 5-hexyn-1-ol (1.69 g, 11.5 mmol) added under a nitrogen atmosphere. After stirring for 10 min, finely ground anhydrous K2CO3 (2.16 g, 15.6 mmol) was added in portions over 2 h, with stirring. The reaction mixture was stirred at 40 C for 48 h under nitrogen. Then the mixture was poured into 400 mL of cold water. The precipitate was filtered off and washed with water, until the filtrate was neutral. Recrystalization from hexane and methanol gives the desired compound as a yellow crystalline powder. Yield: 1.74 g (60%).
The synthetic route of 31643-49-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bankole, Owolabi M.; Britton, Jonathan; Nyokong, Tebello; Polyhedron; vol. 88; (2015); p. 73 – 80;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts