939-80-0, name is 4-Chloro-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 939-80-0
Example 224 Preparation of 6-L-CYCLOHEXYL-5- (1H-TETRAZOL-5-YL)-1H-BENZIMIDAZOL-2-VLL-2- PHENYLQUINOXALINE (Compound 258) Step 1: 4-CYCLOHEXYLAMINO-3-NITROBENZONITRILE (Compound 127); [0776] A solution of 1 g (5.48 mmol) 4-CHLORO-3-NITROBENZONITRILE, Compound 126, and 1.14 g (11. 51 mmol) of cyclohexylamine were heated overnight in 5 mL anhydrous DMF. After cooling to room temperature, the solution was added dropwise into 100 mL H20 stirring vigorously. The solids were collected by filtration and dried under vacuum yielding 1.34 g (100%) bright yellow solids which were used as such without analysis in the next step.
Statistics shows that 939-80-0 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-3-nitrobenzonitrile.
Reference:
Patent; GENELABS TECHNOLOGIES, INC; WO2005/12288; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts