40497-11-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 40497-11-8, name is Ethyl 2,3-dicyanopropanoate, This compound has unique chemical properties. The synthetic route is as follows.
0.01 mol of 2-fluoroaniline and a small amount of ethanol were placed in a 250 mL round bottom three-necked flask, and 3.0 mL (0.035 mol) of concentrated hydrochloric acid was added dropwise with stirring under ice bath. 0.018 mol of sodium nitrite was dissolved in 10 mL of water, and slowly dropped into the flask. After the completion of the dropwise addition, the reaction was carried out for 0.5 h to obtain a yellow diazonium salt solution.Add 0.01 mol of ethyl 2,3-dicyanopropionate to a three-necked flask.The prepared diazonium salt solution was dropped into the flask, and the reaction was added dropwise for 2 hours. Ammonia water was added, the pH was adjusted to 9-10, and the reaction was carried out for 2 h at room temperature. After completion of the reaction, the mixture was extracted with 40 mL of dichloromethane. The organic layer was washed with water (2¡Á30 mL), and washed with saturated sodium chloride solution (1¡Á40 mL), dried over anhydrous magnesium sulfate, and then evaporated. Yield 62.3%, product melting point: 196-198 C.
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Reference:
Patent; Nanjing Tech University; Wan Rong; Chen Fuli; Han Zhenyu; Fu Xiaohuan; Jiang Peng; (17 pag.)CN108203450; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts