As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14618-78-1 name is 4,4-Dimethoxybutanenitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 14618-78-1
In a 500 ml four-necked flask,Add 60 grams of DMF,13.0 g (0.1 mol) of 4,4-dimethoxy-n-butyronitrile,10.0 g (0.11 mol) of 2,3-difluoropropenal,0.8 g DBU, reacted at 80 C for 5 hours,The gas phase detection 1,4-addition reaction is completed.Cool down to 25-30 C,Add 10.0 grams of potassium carbonate,22.0 grams of 17% ammonia,10.0 g of ammonium chloride,Reaction at 80 C for 4 hours,Cool down to 20-25 C,filter,20 grams of ice water wash filter cake,dry,Obtained 11.4 g of 5-fluoro-7-azaindole,Liquid phase purity is 99.2%,The yield was 83.8%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4,4-Dimethoxybutanenitrile, and friends who are interested can also refer to it.
Reference:
Patent; Xin Fa Pharmaceutical Co., Ltd.; Qi Yuxin; Zhang Mingfeng; Wang Sheng; Li Guangqian; Ju Lizhu; (7 pag.)CN110128421; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts