326-62-5, These common heterocyclic compound, 326-62-5, name is 2-(2-Fluorophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-(2-fluorophenyl)acetonitrile (3.000 g, 22.199 mmol) and sodium hydride (60.00%, 1.953 g, 48.838 mmol) in N,N-dimethylformamide (150 mL) at 0 C to this mixture 1,3-dibromopropane (2.253 mL, 22.199 mmol) was added and stirred at 50 C for 17 hours, the temperature was lowered to room temperature, saturated sodium bicarbonate aqueous solution (10 mL) was added to the reaction mixture at 0 C, and the reaction was terminated by stirring for 10 minutes. The solvent was removed from the reaction mixture under reduced pressure, the obtained concentrate was poured into water and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, and water was removed with anhydrous magnesium sulfate, followed by filtration and concentration under reduced pressure. The concentrate was purified by column chromatography (SiO2, 40 g cartridge; ethyl acetate/hexane = 0% to 10%) and concentrated to give the title compound (2.000 g, 51.4%) as a colorless oil.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 326-62-5.
Reference:
Patent; Chong Kun Dang Co., Ltd.; Kim, Yoon Tae; Lee, Chang Sik; Oh, Jung Taek; Song, Hey Sung; Choe, Jin; Lee, Jae Young; (210 pag.)KR2017/43091; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts