1080-74-6, Name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, 1080-74-6, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
As shown in the above reaction formula,The formula (2-8-a-3) obtained in the above Preparation Example 1The compound shown (129 mg, 0.1 mmol),a compound of the formula (a-2-1) (92 mg, 0.4 mmol),Pyridine (0.8 mL, 0.96 mmol) and chloroform(30 mL) was added to the reaction vessel,Argon gas for 25 minutes,It was then refluxed at 65 C for 12 h.After cooling to room temperature (about 25 C),The reaction product was poured into 200 mL of methanol and filtered.The obtained precipitate was sieved on a silica gel column (using 200-300 mesh silica gel,The eluent is a petroleum ether/dichloromethane in a volume ratio of 1:2 for chromatographic separation.Obtained a blue solid (147 mg, yield: 89.1%).That is, the poly-fused ring conjugated macromolecule represented by the formula (1-8-a-3).
Statistics shows that 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile is playing an increasingly important role. we look forward to future research findings about 1080-74-6.
Reference:
Patent; Peking University; Zhan Xiaowei; Zhu Jingshuai; Lin Yuze; (40 pag.)CN109651393; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts