In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 939-80-0 as follows. 939-80-0
In a reactor, compound 2 (917 mg, 2.0 mmol), compound 4 (274 mg, 3.0 mmol) and Cs2CO3 (325 mg, 1.0 mmol) were added to dry THF (20 mL). Then the reactor was sealed under nitrogen, and the mixture was kept at 30 C., stirred for 12 hours. After the reaction, the mixture was diluted with dichloromethane (10 mL) and then filtered. The resulting filtrate was washed twice with water (2¡Á10 mL), and aqueous phases were combined, then the combined aqueous phases were extracted twice with dichloromethane (2¡Á10 mL). The organic layers were combined, dried over Na2SO4, and concentrated to obtain compound XVII as a light yellow powder (1004 mg, yield 90.2%), HPLC purity: 99.2%.
According to the analysis of related databases, 939-80-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; XU, YONG; (10 pag.)US2016/257667; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts