1080-74-6, Name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, 1080-74-6, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
Compound 4 (0.15 g, 0.1275 mmol) and 2-(3-oxo-2,3-dihydroinden-1-ylidene)malononitrile (0.371 g, 3.825 mmol) were dissolved inchloroform (15 mL). A drop of pyridine was added and the solution wasleft to stir at 65 C overnight. The reaction was dissolved in ethanol andstirred for another 10 min. The product was extracted with dichloromethaneand dried over MgSO4. After removal of the solvent, thecrude product was chromatographically purified on silica gel column(eluted with chlorobenzene) to afford dark purple solid (105 mg, 85%).1H NMR (500 MHz, CDCl3) delta: 8.95 (s, 3H), 8.75 (m, 3H), 8.50 (m, 3H),8.01 (m, 3H), 7.98 (m, 6H), 7.91 (s, 3H), 7.83 (m, 6H), 7.69 (d, 3H),3.04 (m, 6H), 2.28 (m, 6H), 0.95 (m, 36H), 0.62 (m, 30H). 13C NMR (125 MHz, CDCl3) delta: 187.44, 159.75, 159.54, 153.77, 145.88, 145.39,141.05, 139.05, 137.13, 136.97, 135.96, 135.41, 134.29, 133.62,130.51, 124.42, 124.40, 124.27, 123.99, 122.85, 121.62, 119.14,113.53, 113.46, 70.06, 56.40, 37.23, 31.63, 29.57, 24.22, 22.41, 14.02.MS (MALDI-TOF) calculated for C114H108N6O3S3, 1705.77; found,1705.94.
Statistics shows that 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile is playing an increasingly important role. we look forward to future research findings about 1080-74-6.
Reference:
Article; Lin, Kaiwen; Xie, Boming; Wang, Zhenfeng; Xie, Ruihao; Huang, Yunping; Duan, Chunhui; Huang, Fei; Cao, Yong; Organic electronics; vol. 52; (2018); p. 42 – 50;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts