Reference of 4592-94-3, These common heterocyclic compound, 4592-94-3, name is 3-(4-Bromophenyl)-3-oxopropanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a stirred solution of 3-oxo-3-aryl-propionitriles 2 and Et3N (0.101 g, 1 mmol) inCH3OH:H2O (2:1, 6 mL) was added adducts of acenaphthoquinone and malononitrile or ethylcycnoacetate 1 (1 mmol) at room temperature. After completion of the reaction [about 30-120min, TLC (n-hexan/EtOAc, 2:1) monitoring], the solvent was evaporated under vacuum and thecrude product was purified by flash column chromatography on silica gel using EtOAc/n-hexane(1:2) as eluent (for compound 3a-d) and or was washed by methanol (for compounds 3e-h) toafford the pure product 3.
Statistics shows that 3-(4-Bromophenyl)-3-oxopropanenitrile is playing an increasingly important role. we look forward to future research findings about 4592-94-3.
Reference:
Article; Yavari, Issa; Khajeh-Khezri, Aliyeh; Bahemmat, Samira; Halvagar, Mohammad Reza; Synlett; vol. 28; 14; (2017); p. 1785 – 1788;,
Nitrile – Wikipedia,
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