Reference of 36282-26-5,Some common heterocyclic compound, 36282-26-5, name is 2-Bromo-4-fluorobenzonitrile, molecular formula is C7H3BrFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Sodium hydride (168 mg, 7.02 mmol, 1.0 eq. ) was added to a solution of 6, 6-dimethyl-3-trifluoromethyl-1, 5, 6, 7- tetrahydro-indazol-4-one (1.63 g, 7.02 mmol, 1.0 eq. ) in 35 mL of anhydrous dimethyl sulfoxide. After 15 min 2-bromo-4- fluorobenzonitrile (2.25 g, 11.23 mmol, 1.6 eq. ) was added as a solid. The reaction mixture was heated at 45 0C. After 23 h the reaction mixture was cooled to ambient temperature and quenched with 10 mL of saturated aqueous ammonium chloride. The mixture was diluted with water and extracted with ethyl acetate (4x) . The combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was purified on a Biotage (SiO2, hexanes-ethyl acetate) to afford 2-bromo-4- (6, 6-dimethyl-4- oxo-3-trifluoromethyl-4, 5,6, 7-tetrahydro-indazol-l-yl) – benzonitrile (1.83 g, 63%) as an off-white powder, LC/MS: (M+H) = 412.0.
The synthetic route of 36282-26-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SERENEX, INC.; WO2006/91963; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts