Reference of 1953-99-7, These common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
100 mL flask Of Synthesis Example 1-2 4- (2-tert-Butyl-4-methoxy-phenoxy) -3,5,6-trichloro-phthalonitrile (1.1 g) 3,4,5,6-Tetrachlorophthalonitrile (0.71 g), 1,8-Diazabicycloundec-7-ene (1.02 g) And 1-pentanol (14 g) were added, and the mixture was heated at 90 ¡ã C to dissolve the solid. Then, zinc acetate (0.25 g) was added thereto and stirred while heating to 140 ¡ã C. After completion of the reaction, precipitation was confirmed with methanol, followed by filtration and vacuum drying. The dried solid is purified by column chromatography. Dichloromethane is appropriately added to the solid obtained after purification to dissolve the solid, and then methanol is added to crystallize. The crystallized solid is filtered and dried under vacuum to obtain a compound represented by the following general formula (10).
The synthetic route of 1953-99-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Samsung SDI Co., Ltd; Shin Myeong-yeop; Seo Hye-won; Jeong Ui-su; Han Gyu-seok; (41 pag.)KR2019/27185; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts