Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 198633-76-0, name is 2-Fluoro-6-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 198633-76-0
To a cooled (0 0C) solution of 2-fluoro-6-methylbenzonitrile (5.0 g, 37 mmol) in 100 r¡ãL of concentrated H2SO4 was added NBS (6.93 g, 38.9 mmol). Then the mixture was stirred at 0 0C for 3 hrs and poured into ice-water (1 L). The solution was extracted three times with EtOAc(200 mL) and the combined orgianc layers were washed with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by silica gel fash chromatography to give 3-bromo-6-fluoro-2-methylbe?zonitrile.1H-NMR (400 MHz, CDCl3) S ppm 7.71-7.74 (m, IH), 6.95 (t, J=8.6 Hz, IH), 2.62 (s, 3H).
According to the analysis of related databases, 198633-76-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP &; DOHME CORP.; PASTERNAK, Alexander; SHAHRIPOUR, Aurash; TANG, Haifeng; TEUMELSAN, Nardos, H.; YANG, Lihu; ZHU, Yuping; WALSH, Shawn, P.; WO2010/129379; (2010); A1;,
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