Adding a certain compound to certain chemical reactions, such as: 64248-62-0, name is 3,4-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 64248-62-0, Application In Synthesis of 3,4-Difluorobenzonitrile
The reaction flask (250 mL) containing magnetic stirring bar was charged with 1,3,5-tris((trimethylsilyl)oxy)benzene (10.28 g, 30 mmol),followed by the addition of 3,4 -difluorobenzonitrile (13.90 g, 100 mmol). The reaction flask was purged with Argon, and anhydrous DMF (100mL) was added. Anhydrous cesium fluoride (1.52 g, 10 mmol) was carefully added in one portion, the reaction flask was capped with a septumconnected to a bubbler and stirred at 120 C for 24 hours. The reaction mixture was poured in water under vigorous stirring and the resultingprecipitate was filtered off and air dried. The title product was obtained after the re-crystallization from ethanol. The product was obtainedafter filtration as a white powder (9.2 g, 63 %).
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Reference:
Article; Chen, Hao; Cheng, Long; Dai, Sheng; Guo, Wei; Jiang, De-en; Jie, Kecheng; Jin, Wanqin; Liu, Gongping; Mahurin, Shannon Mark; Meyer, Harry M.; Popovs, Ilja; Wang, Song; Yang, Zhenzhen; Chem; vol. 6; 3; (2020); p. 631 – 645;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts