Adding a certain compound to certain chemical reactions, such as: 2338-75-2, name is 4-(Trifluoromethyl)phenylacetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2338-75-2, category: nitriles-buliding-blocks
A solution of 5.0 g (27 mmol) of 4-(trifluoromethyl)phenylacetonitrile in 60 mL 2 M MeOH / NH3 was treated with 0.7 g of Raney Nickel. The mixture was then shaken on a Parr Apparatus under 50 psi of hydrogen for 18 h. The mixture was filtered through celite and the filtrate was concentrated in vacuo to afford 4.62 g of the product amine as brown oil. 1H NMR (CDC13, 400 MHz) 8:7.56-7.58, (d, 2H), 7.32- 7.34 (d, 2H), 3.00 (t, 2H), 2.8 (t, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(Trifluoromethyl)phenylacetonitrile, and friends who are interested can also refer to it.
Reference:
Patent; MERCK & CO., INC.; WO2005/110409; (2005); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts