The synthetic route of 6629-04-5 has been constantly updated, and we look forward to future research findings.
In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6629-04-5, name is N-Cyanoacetylurethane belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: N-Cyanoacetylurethane
A mixture of 6-(4-amino-2,6-dichloro-phenylsuhcanyl)-4-isopropyl-2H-pyridazin-3-one (85) (3.40 g, 10.4 mmol) in water (135 mL) and concentrated hydrochloric acid (68 mL) cooled to 00C was treated with a solution of sodium nitrite (853 mg, 12.36 mmol) in water (7.0 mL) via Pasteur pipette under the surface of the reaction mixture. This was followed by a EPO water rinse (1.0 mL) of the Pasteur pipette. The resulting yellow mixture was stirred at 00C for 30 min. More concentrated hydrochloric acid (7.0 mL) was added. The reaction was stirred at 00C for an additional 1.3 h. The solids were removed by filtration through filter paper and were rinsed with water. The clear, yellow diazonium salt solution of the filtrate was quickly poured into a solution of cyanoacetylurethane (1.77 g, 11.33 mmol), pyridine (75 mL) and water (204 mL) cooled to 00C. Upon mixing, orange-red solids immediately formed. This mixture was stirred at 00C for 1 h. At this time, the solids were collected by filtration through filter paper. The solids were washed with water, air-dried under house vacuum for 2 h, and then dried under vacuum to afford (2-cyano-2-{ [3,5-dichloro-4-(5- isopropyl-6-oxo- 1 ,6-dihydro-pyridazin-3-ylsulfanyi)-phenyi] -hydrazono } -acetyl)-carbamic acid ethyl ester (86) (2.98 g, 58%) as an orange solid; ES(+)-HRMS m/e calcd for Ci9Hi8Cl2N6O4S (M+H)+ 497.0560, found 497.0559. Exact Mass = 496.0487; Molecular weight = 497.36
The synthetic route of 6629-04-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2007/9913; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts