Research on new synthetic routes about 3759-28-2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(Cyanomethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.

Electric Literature of 3759-28-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3759-28-2, name is 2-(Cyanomethyl)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of 1-aryl/alkyl-3,3-bis-methylsulfanyl-propenone (1.0 mmol), 2-cyanomethyl-benzonitrile (1 mmol, 142.0 mg), and powdered KOH (2 mmol, 112.0 mg) in dry DMSO (5 mL) was stirred at room temperature for 2 h. Completion of reaction was monitored by TLC. After completion, reaction mixture was poured onto ice-water with constant stirring and then neutralized with 10% HCl. The precipitate obtained was filtered, washed with water and dried over dry sodium sulfate. Many compounds were purified by recrystallization in dry methanol. Some compounds were purified through column chromatography using 15% ethylacetate in hexane as an eluent. Characterization data for some of the synthesized compounds are reported earlier.17

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(Cyanomethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Singh, Surjeet; Althagafi, Ismail; Yadav, Pratik; Panwar, Rahul; Kumar, Abhinav; Pratap, Ramendra; Tetrahedron; vol. 70; 46; (2014); p. 8879 – 8884;,
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Extended knowledge of 1953-99-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1953-99-7, its application will become more common.

Some common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, molecular formula is C8Cl4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: nitriles-buliding-blocks

0.60g (0.015 mol) of sodium hydroxide was added to a solution of 1.22g(0.0075 mol) of 3,5-dichloropyridin-4-amine in 40 mL of DMF, followed by addition of 2g (0.0075 mol) of 3,4,5,6-tetrachlorophthalonitrile under stirring, themixture was stirred for 5 h after addition at room temperature. After the reaction was over by Thin-Layer Chromatographymonitoring, the reaction mixture was poured into water and extracted with ethyl acetate, the organic phase was washedwith water and saturated brine, dried over anhydrous magnesium sulfate, filtered and then concentrated under reducedpressure. The residue was purified through silica column (ethyl acetate/petroleum ether (boiling point range 60-90¡ãC)= 1:4, as an eluent) to give 2.6 g of compound A-87 as yellow solid, m.p. 214-216¡ãC.[0070] 1H-NMR (300MHz, internal standard TMS, solvent DMSO), 8.26(s, 2H, Py-2,6-2H), 11.0(br, 1H, NH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1953-99-7, its application will become more common.

Reference:
Patent; Sinochem Corporation; Shenyang Research Institute of Chemical Industry Co., Ltd.; LIU, Changling; HUANG, Guang; LAN, Jie; HAO, Shulin; LI, Zhinian; LI, Huichao; GUAN, Aiying; JIANG, Airu; XU, Ying; EP2757092; (2014); A1;,
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The origin of a common compound about 92616-49-4

The synthetic route of 4-Bromo-1-naphthonitrile has been constantly updated, and we look forward to future research findings.

Synthetic Route of 92616-49-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 92616-49-4, name is 4-Bromo-1-naphthonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 4-bromo-1-naphthonitrile (230 mg, 0.991 mmol), bis(pinacolato)diboron (277 mg,1.090 mmol), potassium acetate (292 mg, 2.97 mmol) in DMSO (2 ml) was degassed and treatedwith PdC12(dppf) (21.75 mg, 0.030 mmol). The mixture was then capped and heated to 80 Covernight. The reaction mixture was then washed with water and exctracted with ethyl acetate. Theorganics were collected, dried, filtered, and concentrated. The mixture was purified by silica gel chromatography (24 G, 0-50% EtOAc-hexanes) to provide 4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-1-naphthonitrile as a white solid (118 mg, 43%). 1H NMR (400 MHz, Chloroform-d) 8.86-8.80 (m, 1H), 8.30-8.24 (m, 1H), 8.08 (d, J= 7.1 Hz, 1H), 7.89 (d, J 7.1Hz, 1H), 7.71 – 7.62 (m, 2H), 1.44 (s, 12H).

The synthetic route of 4-Bromo-1-naphthonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE BRIGHAM AND WOMEN’S HOSPITAL, INC.; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; LEE, Arthur; MCKEW, John, C.; PATEL, Paresma, R.; YU, Paul, B.; MOHEDAS, Agustin, H.; SANDERSON, Philip, E.; ZHENG, Wei; HUANG, Xiuli; UNIVERSITY OF HOUSTON SYSTEM; CUNY, Gregory, D.; (304 pag.)WO2016/11019; (2016); A1;,
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Discovery of 21803-75-8

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 21803-75-8, its application will become more common.

Some common heterocyclic compound, 21803-75-8, name is 4-Amino-3-chlorobenzonitrile, molecular formula is C7H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 4-Amino-3-chlorobenzonitrile

General procedure: To an ice-cold suspension of nicotinoyl chloride hydrochloride(I) (1.78 g, 10 mmol) and appropriate 4-aminobenzonitrile (IIa-g) (10 mmol, 1.0 equiv) in acetonitrile(50 ml) under nitrogen was added triethylamine (8.1 g, 11.15 ml,40 mmol, 4.0 equiv) dropwise over 30 min. The resulting suspensionwas stirred at 0 C for 1 h then at room temperatureovernight. The reaction mixture was evaporated, diluted withEtOAc, washed with 10% HCl, brine, dried over anhydrousNa2SO4 and concentrated in vacuo. The resulting solid waswashed with diethyl ether and dried to yield the desired compounds(IIIa-g) in 50-90% yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 21803-75-8, its application will become more common.

Reference:
Article; Dokla, Eman M.E.; Fang, Chun-Sheng; Abouzid, Khaled A.M.; Chen, Ching S.; European Journal of Medicinal Chemistry; vol. 182; (2019);,
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The origin of a common compound about 51762-67-5

According to the analysis of related databases, 51762-67-5, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51762-67-5 as follows. Recommanded Product: 51762-67-5

General procedure: (1R,2R)-1,2-bis(3-phenylphenyl)ethane-1,2-diol 1 (1.0 mmol,1.0 equiv.) and 4mL of DMSO were placed in two-neck flask under anitrogen atmosphere at room temperature. To this reaction mixturewas added 3- or 4-nitrophthalonitrile (1.0 mmol, 1.0 equiv.) andstirred for 15 min under inert atmosphere. Finely ground anhydrousK2CO3 (1.0 mmol, 1.0 equiv.) was then added to the resultingmixture at room temperature. The reaction was monitored by thin layer chromatography and completed in 2 h. The reaction mixturewas poured into water-ice (1:3 v/v) resulting in the formation oflight-yellow precipitate and then extracted with dichloromethane.The combined organic layer was dried over anhydrous Na2SO4 andthe solvent was evaporated under reduced pressure to give a crudeproduct that was purified by silica gel chromatography. The elutionwas carried out with dichloromethaneeethyl acetate (95:5).

According to the analysis of related databases, 51762-67-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Goek, Halil Zeki; Goek, Ya?ar; Journal of Molecular Structure; vol. 1206; (2020);,
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Brief introduction of 939-80-0

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-3-nitrobenzonitrile, and friends who are interested can also refer to it.

Related Products of 939-80-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 939-80-0 name is 4-Chloro-3-nitrobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 3a Preparation of 4-chloro-3-aminobenzonitrile A degassed solution of 40 mmol of 4-chloro-3-nitrobenzonitrile (starting material) and 40 ml of xylene are placed in an autoclave (volume: 200 ml).5.0 mmol of TPPTS (in the form of 9.2 g of an aqueous solution containing 0.546 mol of TPPTS/kg of solution) as phosphine and 2.4 g (60 mmol) of NaOH, 23.8 ml of H2 O and 1.0 mmol of PdCl2 are added. The pH isfrom 10.5 to 11.0. The autoclave is closed, evacuated and filled with nitrogen. The evacuationand filling with nitrogen is repeated twice, then the autoclave is filled with CO, evacuated and refilled with CO. The evacuation and filling with CO is repeated twice. The autoclave is subsequently pressurized with CO to a pressure of 120 bar and the mixture is heated to 100 C. while stirring. The reaction time is 20 hours. The mixture is subsequently cooled to room temperature, the autoclave is emptied and the organic phase is separated from the aqueous phase. The organic phase is filtered to remove traces of palladiumand evaporated under reduced pressure, with the desired product being purified, if desired by crystallization or chromatography.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-3-nitrobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Hoechst Aktiengesellschaft; US5744643; (1998); A;,
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Analyzing the synthesis route of 53312-82-6

The synthetic route of 4-Amino-2-bromobenzonitrile has been constantly updated, and we look forward to future research findings.

Synthetic Route of 53312-82-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53312-82-6, name is 4-Amino-2-bromobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

4-amino-2-bromobenzonitrile (0.055 g, 0.281 mmol) was stirred in dichloromethane (2 mL) and 0.50 mL saturated sodium bicarbonate solution (0.024 g, 0.281 mmol) solution at 0 C. Phosgene (20% in toluene, 0.3 mL, 0.561 mmol) was added and stirred for 30 min. The organic layer was extracted with dichloromethane and washed with water followed by sodium bicarbonate solution. The organic layer was concentrated and redissolved in DMF (2 mL). 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine (0.050 g, 0.281 mmol) was added and heated at 90 C for 1 h. The resulting solid was filtered and washed with water, ethyl acetate and acetone to yield compound 24 as a pure solid (0.045 g, 0.112 mmol, 40%). See below for characterization data.

The synthetic route of 4-Amino-2-bromobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rosenthal, Andrew S.; Dexheimer, Thomas S.; Gileadi, Opher; Nguyen, Giang H.; Chu, Wai Kit; Hickson, Ian D.; Jadhav, Ajit; Simeonov, Anton; Maloney, David J.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 20; (2013); p. 5660 – 5666;,
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New learning discoveries about 328-87-0

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 328-87-0, name is 2-Chloro-5-trifluoromethylbenzonitrile, A new synthetic method of this compound is introduced below., name: 2-Chloro-5-trifluoromethylbenzonitrile

Preparation of 2-cyano-alpha,alpha,alpha-trifluoro-p-tolyl-4-nitro phenyl ether A solution of potassium hydroxide (3.2 g. 0.05 mole of 89.3% purity) and p-nitrophenol (7.0 g. 0.05 mole) in methanol (25 ml.) is stripped under reduced pressure. The residue is dissolved in sulfolane, 4-chloro-3-cyano alpha,alpha,alpha-trifluorotoluene (10.3 g. 0.05 mole) added, and the resulting solution heated at 150 C for 5 hours. After cooling, the solution is diluted with benzene (350 ml.) washed with water (6 * 250 ml.), dried, and the solvent removed. The residue (12.5 g.) is recrystallized from isopropanol to give 2-cyano-alpha,alpha,alpha-trifluoro-p-tolyl-4-nitrophenyl ether (7.6 g., 49%) m.p. 93-98 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Rohm and Haas Company; US4076741; (1978); A;,
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Some tips on 72115-09-4

The synthetic route of 72115-09-4 has been constantly updated, and we look forward to future research findings.

Application of 72115-09-4, These common heterocyclic compound, 72115-09-4, name is 5-Amino-2-bromobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-Amino-2-bromobenzonitrile (500 mg, 2.54 mmol), 4-(4,4,5,5-tetramethyl-1 ,3,2- dioxaborolan-2-yl)-3,6-dihydro-2H-pyran (559 mg, 2.67 mmol) and potassium carbonate (701 mg, 5.08 mmol) were dissolved in DME (10 mL) and water (5 mL). The reaction mixture was degassed under a stream of nitrogen before bis(triphenylphosphine) palladium(ll) dichloride (89 mg, 0.13 mmol) was added. The reaction mixture was stirred at 100 C for 2 hours. After this time the reaction was complete and the reaction mixture was cooled to room temperature. Water (15 mL) was added to the reaction mixture and this was extracted with DCM (3 x 10 mL). The combined organics were dried (MgS04), filtered and concentrated under reduced pressure. The crude material was purified by flash chromatography (Si02, EtOAc/heptane 0-100%) to afford 270 mg (50% yield) of the title compound.1H NMR (250 MHz, DMSO-d6) delta [ppm] 2.29 – 2.40 (m, 2H), 3.79 (t, J = 5.4 Hz, 2H), 4.18 (q, J = 2.8 Hz, 2H), 5.59 (s, 2H), 5.82 – 5.96 (m, 1 H), 6.71 – 6.90 (m, 2H), 7.14 (d, J = 8.3 Hz, 1 H).LCMS (Analytical Method A): Rt = 0.92 mins; MS (ESIpos) m/z = 201 (M+H)

The synthetic route of 72115-09-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeURLE, Stefan; DAVENPORT, Adam, James; STIMSON, Christopher; CARR, James, Lindsay; BUBERT, Christian, Abingdon; MARLIN, Frederic, Jacques; NAGEL, Jens; SCHMIDT, Nicole; ROTGERI, Andrea; IRLBACHER, Horst; (378 pag.)WO2018/114783; (2018); A1;,
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Research on new synthetic routes about 67515-59-7

The chemical industry reduces the impact on the environment during synthesis 4-Fluoro-3-(trifluoromethyl)benzonitrile. I believe this compound will play a more active role in future production and life.

Synthetic Route of 67515-59-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67515-59-7, name is 4-Fluoro-3-(trifluoromethyl)benzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

A solution of vanillin (1.65 g, 10.86 mmol) and 4-fluoro-3-trifluoromethyl-benzonitrile (10.26 mmol) in DMF (15 mL) was treated with K2CO3 (2.83 g, 21.72 mmol), and the mixture was heated in an oil bath at 80 C. for 12 h. The reaction was cooled to RT and partitioned between EtOAc and H2O. The organic phase was washed with water (3¡Á), dried over Na2SO4 and concentrated in vacuo. Silica gel chromtagraphy (EtOAc/hexanes) afforded the title compound. 1H NMR (400 Hz, CDCl3) delta 10.00 (s, 1H), 8.00 (m, 1H), 7.68 (dd, 1H), 7.58-7.53 (m, 2H), 7.29 (d, 1H), 6.75 (d, 1H), 3.83 (s, 3H); LC/MS (m/z) [M+1]+ 322.1 (calculated for C16H11F3NO3, 322.06).

The chemical industry reduces the impact on the environment during synthesis 4-Fluoro-3-(trifluoromethyl)benzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Gaul, Michael; Searle, Lily Lee; Rentzeperis, Dionisios; US2008/286265; (2008); A1;,
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