Adding a certain compound to certain chemical reactions, such as: 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1080-74-6, SDS of cas: 1080-74-6
General procedure: Compound T-TT-CHO (200 mg, 0.2 mmol), INCN (246 mg, 1.2 mmol), and chloroform (30 mL) were added into a 100 mL round bottom flask. After stirred for 10 min under argon protection, pyridine (1 mL) was added by injection and the mixture was stirred at 70C for 6 h. Then methanol (100 mL) was added and the precipitate was collected by filtration after removing the chloroform under reduced pressure. The residue was purified by column chromatography using chloroform as an eluent to give a blue-black powder (226 mg, 84.0%).
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Reference:
Article; Cheng, Qing; Cong, Zhiyuan; Gao, Chao; Liu, Jianqun; Liu, Shengna; Pan, Hui; Wang, Weiping; Wu, Haimei; Zhao, Baofeng; Dyes and Pigments; vol. 178; (2020);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts