Adding a certain compound to certain chemical reactions, such as: 658-99-1, name is 2-(3,4-Difluorophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 658-99-1, Computed Properties of C8H5F2N
2-(3,4-difluorophenyl)acetonitrile (7.730 g, 50.480 mmol) in N,N-dimethylformamide (50 mL) at 0 C and sodium hydride (60.00%, 5.047 g, 126.200 mmol) was added and stirred at the same temperature for 30 minutes. To the reaction mixture 1,3-dibromopropane (10.191 g, 50.480 mmol) was added and further stirred at room temperature for 12 hours. The reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, and water was removed with anhydrous magnesium sulfate, followed by filtration and concentration under reduced pressure. The concentrate was purified by column chromatography (SiO2, 40 g cartridge; ethyl acetate / hexane = 0% to 20%) and concentrated to give the title compound (5.100 g, 52.3%) as a colorless oil.
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Reference:
Patent; Chong Kun Dang Co., Ltd.; Kim, Yoon Tae; Lee, Chang Sik; Oh, Jung Taek; Song, Hey Sung; Choe, Jin; Lee, Jae Young; (210 pag.)KR2017/43091; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts