In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 935-44-4, name is 1-Phenyl-1-cyclopropanecarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C10H9N
INTERMEDIATE 45 4-(1-Cyanocyclopropyl)benzenesulfonyl chloride To a solution of 1-phenylcyclopropanecarbonitrile (0.5 g, 3.5 mmol) in 5 mL of chloroform was added 0.5 mL of ClSO3H at 0 C. After stirring at rt stirred overnight, the reaction mixture was poured into ice-water (50 mL) and the product was extracted with CHCl3 (75 mL). The extracts were washed with water (50 mL) and brine (50 mL), dried over anhydrous MgSO4, and concentrated to give the title compound. 1H NMR (500 MHz, CD3OD): delta 8.08 (2H, d), 7.77 (2H, d), 1.60 (2H, t), 1.21 (2H, t).
The synthetic route of 935-44-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck Sharp & Dohme Corp.; EP2102201; (2010); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts