Related Products of 127946-77-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of (S)-2-((ieri-butoxycarbonyl)amino)-3-(3-chloro-4-(trifluoromethoxy)- phenyl)propanoic acid (example la; 3.52 g, 9.17 mmol, Eq: 1) in DMF (40 ml) 1- aminocyclopropanecarbonitrile hydrochloride (1.31 g, 11 mmol, Eq: 1.2), HATU (6.98 g, 18.3 mmol, Eq: 2) and /Pr2Net (4.15 g, 5.61 ml, 32.1 mmol, Eq: 3.5) were added at 0 C under an Argon atmosphere. The mixture was stirred for 3h, during that time to the mixture was warmed up to 25 C. After that the mixture was diluted with EtOAc. The organic phase was extracted with water (2x) and brine (3x), dried over Na2S04, filtered, and evaporated to dryness. The mixture was purified by flash chromatography (Si02; CH2Cl2/EtOAc, gradient from 100:0 to 0: 100 within 40 min) to yield the title compound (3.14 g; 76.4%) as a yellow solid. MS (ESI): m/z = 446.1 [M-H] .
The synthetic route of 1-Amino-1-cyclopropanecarbonitrile hydrochloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GIROUD, Maude; HAAP, Wolfgang; KUHN, Bernd; MARTIN, Rainer E.; (75 pag.)WO2017/89389; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts