Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31643-49-9, name is 4-Nitrophthalonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 31643-49-9
The synthesis of 2 was similar to 1, but 4-hydroxybenzaldehyde wasemployed instead of dimethoxy phenyl ethanol. The reaction mixturewas stirred under N2 at room temperature for 24 h. The other reagentswere 4-nitrophthalonitrile (1 g, 5.55 mmol) and anhydrous K2CO3 (2 g,13.88 mmol). Compound 2 was obtained as: White solid; m.p. 350 C;yield 67%; FTIR (KBr) (n cm-1): 3077 (Ar-CH), 2227 (C?N), 1601(C=C), 1263 (C-O-C); 1H NMR (400 MHz, DMSO-d6): delta 7.49 (d,1H, H2¡é), 7.56 (d, 1H, H6¡é), 7.70 (d,1H, H3¡é), 7.74 (d, 1H, H5¡é), 7.86 (d,1H, H5), 7.89 (s, 1H, H3), 8.15 (d, 1H, H6), 10.02 (s, 1H, Hald); 13C NMR(100 MHz, DMSO-d6, tamb): delta 109.3 (C1), 115.7 (C2), 116.2 (C4¡é), 117.3(CN), 116.2 (CN), 120.8 (C2¡é), 123.6 (C6¡é), 126.7 (C3¡é,5¡é), 132.0 (C3),136.8 (C5), 138.8 (C6), 155.1 (C4), 160.8 (C1¡é), 192.7 (Cald); ESI-SMHRm/z: 249.23 [M + H]+. Anal. calcd for C15H8N2O2: C, 72.57; H, 3.24; N,11.28; found: C, 72.4; H, 3.1; N, 11.2%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Medyouni; Hallouma; Mansour; Al-Quraishy; Hamdi; Journal of Chemical Research; vol. 41; 5; (2017); p. 291 – 295;,
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