Reference of 1080-74-6, A common heterocyclic compound, 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, molecular formula is C12H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The compound represented by Formula (2-11A-1) obtained in the above Preparation Example 2 (163.1 mg, 0.1 mmol), the compound represented by Formula (a-2-1) (78 mg, 0.4 mmol; purchased from TCI), Pyridine (0.8 mL, 0.96 mmol) and chloroform (30 mL) were added to the reaction vessel, argon was passed for 25 min, and then refluxed at 65 C. for 15 h. After cooling to room temperature (approximately 25 C), the reaction product was poured into 200 mL of methanol and filtered. The obtained precipitate was subjected to a silica gel chromatography column (200-300 mesh silica gel was used, and the eluent was petroleum ether with a volume ratio of 1: 2. / Dichloromethane) and chromatographically separated to obtain a green solid (178.3 mg, yield 90.0%), which is a two-dimensional fused ring conjugated macromolecule represented by the formula (1-11A-1).
The synthetic route of 1080-74-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Peking University; Zhan Xiaowei; Wang Jiayu; (34 pag.)CN110386943; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts