Application of 31643-49-9,Some common heterocyclic compound, 31643-49-9, name is 4-Nitrophthalonitrile, molecular formula is C8H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-Nitro-phthalonitrile (0.866 g, 5 mmol) and 4-hydroxybenzoic acid (0.69 g, 5 mmol) were added successively with stirring to dry DMF (10 ml). After dissolution, anhydrous K2CO3 (1.0 g, 7 mmol) was added and the reaction mixture was stirred at 60 C. Further K2CO3 (0.5 g, 3.5 mmol) was added portion-wise after 2 h. After stirring vigorously the reaction mixture for 24 h under nitrogen, the undissolved salt was removed by filtration. The solution was concentrated under vacuum till a precipitate was obtained. Then the precipitate was crystallized from EtOH-water to give the product as a mahogany, crystalline powder. Yield: 0.81 g, 61.3%, m.p. 252-255 C. IR (KBr), upsilon (cm-1): 3398 (OH), 3099 (HAr), 2230 (CN), 1663 (CO) 1591, (Ar CC), 1256 (ArOAr). 1H NMR (DMSO-d6) delta, ppm: 7.03-8.04 (m, 7H, ArH). Anal. Calc. for C15H8N2O3 (264.24 g/mol): C, 71.98; H, 3.05; N, 10.60; O, 18.16 Found: C, 72.04; H, 3.01; N, 10.53.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Nitrophthalonitrile, its application will become more common.
Reference:
Article; Zhang, Xuejun; Mao, Lijun; Zhang, Dan; Zhang, Lei; Journal of Molecular Structure; vol. 1022; (2012); p. 153 – 158;,
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