Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 621-03-4, name is 2-Cyano-N-phenylacetamide, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks
General procedure: To a well-stirred solution of 2-cyano-N-(methyl)acetamide (10 g, 102 mmol) in dry DMF (154 ml) was added crushed potassium fluoride (118 g, 2040 mmol) and the reaction mixture was cooled to 0C. Carbon disulphide (7.4 ml, 122.4 mmol) was carefully added and the resultant yellow mixture was stirred for 30 min at the same temperature. Methyl iodide (12.7 ml, 204 mmol) was then added drop-wise over 5 min. After stirring for 1 h at 0 C, the mixture was stirred at room temperature for 12 h. The mixture was then diluted with ice-cold water and the precipitated ketene dithioacetal was collected by filtration. The crude product was purified by recrystallisation from a mixture of ethyl acetate and petroleum ether to yield 18.3 g (89%) of the product as yellow solid
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Kumar, Sukeerthi; Thakur, Rajni R.; Margal, Sanjay R.; Thomas, Abraham; Tetrahedron; vol. 69; 25; (2013); p. 5112 – 5118;,
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