Synthetic Route of 1187-42-4, These common heterocyclic compound, 1187-42-4, name is Diaminomaleonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 100 mL two-necked flask, 2.6 lg (10 mmol) of 5-bromoacenaphthenequinone, 1.08 g (10 mmol) of diaminomaleonitrile, and 60 mL of acetic acid were sequentially added thereto, and the temperature was raised to 120 ¡ã C, and the mixture was stirred under reflux for 24 hours. The mixture was cooled to room temperature, poured into water, filtered under reduced pressure and washed with a large amount of water. The residue was dried and separated and purified on a silica gel column using dichloromethane: petroleum ether = 3:1 (volume ratio) eluent to obtain yellow. 3-bromoacenaphthenequinoneopyrazine-8,9-dicarbonitrile 2.44g, yield 77¡¤27percent
The synthetic route of 1187-42-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Soochow University (Suzhou); Liao Liangsheng; Yuan Yi; Jiang Zuoquan; Hu Yun; (37 pag.)CN108440424; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts