Reference of 2469-99-0, These common heterocyclic compound, 2469-99-0, name is 3-Oxobutanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirring suspension of 5-hydrazinylisoquinoline (prepared from Example 25 step a, 0.60 g, 3.8 mmol) and 3-oxobutanenitrile (0.31 g, 3.8 mmol) in ethanol (3 mL) was heated at 80 C. for 2 h. After cooling to room temperature, the reaction mixture was in vacuo and the resulting crude residue was purified by flash chromatography (SiO2, 0-20% methanol in ethyl acetate) to give the desired product (0.067 g, 2.8 mmol, 73%).
The synthetic route of 2469-99-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CHEMOCENTRYX, INC.; CHEN, Xi; FAN, Junfa; FAN, Pingchen; KRASINSKI, Antoni; LI, Lianfa; LUI, Rebecca M.; McMAHON, Jeffrey P.; POWERS, Jay P.; ZENG, Yibin; ZHANG, Penglie; US2013/225580; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts