Related Products of 95-11-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 95-11-4 name is 5-Norbornene-2-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
72 g (0.604 mol, 1 equivalent) of 5-norbornenecarbono-2-nitrile, 39.4 g (0.604 mol, 1 equivalent) of potassium cyanide, nickel chloride (II) 6 in a 1 L reactor equipped with a mechanical stirrer, thermometer and dropping funnel 7.2 g (0.03 mol, 0.05 equivalent) of hydrate, 15.84 g (0.06 mol, 0.1 equivalent) of triphenylphosphine, 20.66 g (0.3 mol, 0.5 equivalent) of zinc powder were added and acetone (100 ml), methanol (200 ml), distilled water (100 ml) was added. 36.3 g (0.604 mol, 1 equivalent) of acetic acid was added over 2 hours while maintaining the reaction internal temperature at 5 to 10 C.After the addition, the reaction internal temperature was raised to 70 C. and stirred for 2 hours. Gas chromatography analysis confirmed that the reaction was completed, and the reaction internal temperature was cooled to 25 . 300 ml of toluene was added to the reaction mixture to extract the dicyanobornane produced. The organic layer was washed three times with 300 ml of a 2N hydrochloric acid solution, and the organic layer was passed through a silica pad and concentrated to obtain 77 g of dicyanobornane having a purity of 99%. Yield was 98%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Norbornene-2-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Kes Optics Co., Ltd.; Kim Geun-sik; Kwon O-jun; (9 pag.)KR2019/102853; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts