Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 145689-34-5, name is 2-(2,3-Difluorophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 145689-34-5
Example 1.2 (6S .V (6?8.S)-6-(2,3-Difluo^ <3]pyridin-8-yl]-2l-oxo 25j etrahy ft]pyr idine] -3 -carb xamide Step A: Methyl 2-[(feA-f-butoxycarbonyl)aminol-4-cyano-4-(2,3-difluorophenyl)butanoate To a solution of (2,3-difluorophenyl)acetonitrile (18.6 g, 122 mmol) ?eta Nu,Nu- dimethylformamide (243 mL) at 0 C was added sodium hydride (60% dispersion in mineral oil) (4.37 g, 109 mmol). After 20 min, methyl N~(tert~butoxycarbonyl)~3~iodo-Z)-alaninate (20.0 g, 60.8 mmol) was added, and the resulting mixture stirred 50 min. Saturated aqueous sodium bicarbonate was added, and the mixture was warmed to ambient temperature. Water was added and the mixture was extracted with ethyl acetate (3 ). The combined organic extracts were washed with water (3x), brine, dried over magnesium sulfate, filtered and concentrated. Purification by silica gel chromatography (100% hexanes? 20% hexanes/ ethyl acetate) gave the title compound (12.0 g). MS 377.3 (M+Na),
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 145689-34-5.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BURGEY, Christopher, S.; GINNETTI, Anthony; NOMLAND, Ashley; PAONE, Daniel, V.; WO2013/66360; (2013); A1;,
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