Synthetic Route of 85068-32-2,Some common heterocyclic compound, 85068-32-2, name is 2-(3,5-Bis(trifluoromethyl)phenyl)acetonitrile, molecular formula is C10H5F6N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
An ethanol (10 mL) solution of 3,5-bis(trifluoromethyl)phenylacetonitrile (3.59 g, 14.2 mmol) and 2-ethylsulfanylaniline (2.54 g, 14.2 mmol) was cooled on ice, and an ethanol (10 mL) solution of sodium methoxide (1.2 g, 21.3 mmol) was sequentially added dropwise, followed by stirring under ice cooling for 72 hours. Water was poured in the reaction solution, and the resulting solution was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (eluting solvent: ethyl acetate/hexane=1:6) to afford the title compound (yielded 5.3 g, yield: 87%) as a red-tan oily product. 1HNMR Spectrum (CDCl3) sigma: 8.29 (2H, s), 7.79 (1H, s), 7.58-7.52 (2H, m), 7.44-7.39 (2H, m), 4.00 (2H, br), 2.87 (2H, q, J=7.3 Hz), 1.27 (3H, t, J=7.3 Hz).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(3,5-Bis(trifluoromethyl)phenyl)acetonitrile, its application will become more common.
Reference:
Patent; HOKKO CHEMICAL INDUSTRY CO., LTD.; HIROKI, Hidekatsu; KOBAYASHI, Yuta; SUZUKI, Jun; ONOUE, Shinji; IWASAKI, Katsuhiko; OOTAKA, Akihito; DOI, Hayato; MATSUO, Eiko; ONOUE, Miwa; OKIMOTO, Asako; (68 pag.)US2018/290986; (2018); A1;,
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