Related Products of 1080-74-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Compound 4 (400 mg, 0.47 mmol) and INCN (458 mg, 2.36 mmol) were dissolved in anhydrous chloroform (CF, 25 mL) and 0.3 mL of pyridine was slowly injected into mixture solution. Thereaction was stirred under a nitrogen atmosphere at 65 C for 12 h. Subsequently, the reaction vessel was cooled to room temperature and extracted with chloroform several times. The extracted organic layer were dried over MgSO4, filtered, and evaporated to obtain a residue. The mixture compound was then purified with column chromatography using chloroform to afford a dark solid. Yield = 275 mg (44%) 1H NMR (300 MHz, CDCl3) delta: 8.87 (s, 2H), 8.69(d, 2H), 8.18 (d, 2H), 7.93 (dd, 2H), 7.89 (dd, 2H), 7.82(m, 4H), 7.77 (dd, 2H), 7.53 (t, 4H), 2.91 (t, 4H), 1.75 (t,4H), 1.25 (m, 4H), 0.82 (t, 6H). 13C NMR (75 MHz,CDCl3) delta: 183.06, 166.92, 164.45, 153.73, 147.76, 142.60,140.51, 139.71, 135.59, 134.57, 132.97, 130.86, 128.93,126.83, 122.33, 122.25, 121.59, 105.02, 102.60, 71.85,61.04, 43.95, 41.65, 31.48, 29.79, 29.13, 27.42, 22.8014.51. Anal. Calcd for C64H54N4S2: C, 78.8; H, 5.6;N,5.7; S, 6.6. Found: C, 78.9; H, 5.5; N,5.6; S, 6.6. MS(MALDI-TOF): m/z [M+] = 974.61 [M+], calcd. 974.37.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Lee, Seong Lim; Kim, Hee Su; Ha, Jong-Woon; Park, Hea Jung; Hwang, Do-Hoon; Bulletin of the Korean Chemical Society; vol. 41; 2; (2020); p. 143 – 149;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts