Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 179897-89-3, name is 5-Bromo-2-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 179897-89-3
To a solution of zinc chloride (50 mL, 1. OM in diethyl ether, 50 mmol) was added neopentylmagnesium chloride (50 mL, 1. OM in THF, 50 mmol) dropwise at 0 C. During the addition, the generated magnesium salts formed a white precipitate. The reaction was removed from the ice bath and allowed to stir for 1h, then 1- bromo-2-fluorobenzonitrile (5 g, 25 mmol) was added followed by bis (tri-tert- butylphosphine) palladium (0.127 g, 0.25 mmol, 1%). The reaction began to reflux and was placed back into the ice bath. After 1 h, the reaction was diluted with 200 mL of diethyl ether and washed with 1N HCI (2 x 100 mL), brine (100 mL), dried over magnesium sulfate and concentrated to give an oily solid (4.3 g, 22 mmol, 90%). H NMR (400 MHz, CDC13) 8 7.38-7. 30 (m, 2H), 7.11 (dt, J=8.5, 1.4 Hz, 1 H), 2.49 (s, 2H), 0.90 (s, 9H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 179897-89-3.
Reference:
Patent; ELAN PHARMACEUTICALS, INC.; WO2005/87751; (2005); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts