Synthetic Route of 105-34-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 105-34-0, name is Methyl 2-cyanoacetate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
97 g (0.56 mol) of 1-nitronaphthalene,166.5 g (1.68 mol) of methyl cyanoacetate,40.1 g (0.62 mol) of potassium cyanide,62.9 g (1.12 mol) of potassium hydroxide,And the mixture was stirred.Dimethylformamide 970 mLAnd the mixture was stirred overnight at 60 C.After the solvent was removed by concentration under reduced pressure at room temperature, 10%500 mL of an aqueous solution of sodium hydroxide was added and the mixture was refluxed for about 1 hour.After separation by column chromatography, recrystallization from toluene and heptane gave 50.8 g of intermediate 4-a. (Yield: 54%)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-cyanoacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SFC Ltd.; Choi Yeong-tae; Lee Se-jin; Park Seok-bae; Ryu Tae-jeong; Yang Byeong-seon; Lee Da-jeong; (92 pag.)KR2018/10087; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts