Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4592-94-3, name is 3-(4-Bromophenyl)-3-oxopropanenitrile, A new synthetic method of this compound is introduced below., Quality Control of 3-(4-Bromophenyl)-3-oxopropanenitrile
To a cooled (0C) and stirred solution of 3-(4-bromophenyl)-3-oxopropanenitrile (Example 230, 4.00 g, 17.85 mmol) in THF (20 mL) was added sodium hydride (60% in oil dispersion, 857 mg, 21.4 mmol). After gas evolution ceased, the mixture was warmed to rt, and isatoic anhydride (3.49 g, 17.85 mmol) was added. The reaction was heated to reflux for 16 h and then cooled to rt. The reaction was quenched and adjusted to pH 5 by slow addition of hydrochloric acid (1 N aqueous solution). The resulting white solid was collected by filtration and triturated with diethyl ether/acetone (3:1) to afford 3.5 g (60%) of desired product. 1H NMR (400 MHz, DMSOd6) delta 12.73 (br s, 1 H), 8.13 (dd, 1 H), 7.70-7.87 (m, 6 H), 7.49 (dddd, 1 H); ES-MS m/z 326.8 [M+H]+, HPLC RT (min) 2.95
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2006/34491; (2006); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts