Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, A new synthetic method of this compound is introduced below., Quality Control of 1-Amino-1-cyclopropanecarbonitrile hydrochloride
A solution of 2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5- dihydro- 1 H- 1 ,2,4-triazol- 1 -yl } methyl)- IH- 1 ,2,4-triazol- 1 -yl]pyridine-3-carboxylic acid (Example 33A, 80.0 mg, 157 muiotaetaomicron) in N,N-dimethylformamide (1.0 ml) was treated with HATU (89.5 mg, 235 muiotaetaomicron) and stirred 30 min at room temperature. 1-Aminocyclopropanecarbonitrile hydrochloride (1: 1) (27.9 mg, 235 muiotaetaomicron) was then added followed by and N,N- diisopropylethylamine (120 mu, 710 mumol). The resulting mixture was stirred 2 h at room temperature. Purification by preparative HPLC (Method 4) afforded 72.0 mg (80 % of th.) of the title compound. LC-MS (Method 2): Rt = 1.60 min; MS (ESIpos): m/z = 574.1 [M+H]+ -NMR (400 MHz, DMSO-d6) delta [ppm] : 9.23 (d, 2H), 8.64 (dd, IH), 8.08 (dd, IH), 7.83-7.53 (m, 5H), 6.92 (d, IH), 5.08 (s, 2H), 4.41-4.21 (m, IH), 4.08-3.75 (m, 2H), 1.60-1.11 (m, 4H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; COLLIN-KROePELIN, Marie-Pierre; KOLKHOF, Peter; NEUBAUER, Thomas; FUeRSTNER, Chantal; POOK, Elisabeth; WITTWER, Matthias, Beat; LUSTIG, Klemens; TINEL, Hanna; LINDNER, Niels; SCHIRMER, Heiko; (449 pag.)WO2019/81307; (2019); A1;,
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