Reference of 1735-88-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1735-88-2 name is 2-Cyano-N-(4-fluorophenyl)acetamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 2-cyano-N-(4-fluorophenyl)acetamide (1.78 g, 0.01 mol) in ethanol (20ml) was added piperidine and 3,4-dihydroxy-5-nitrobenzaldehyde (1.83 g, 0.01 mol). The reaction mass was heated to 70-75 C for 2-3 hours. After completion of the reaction, the solid that formed was filtered off. To the solid was added demineralized water and the mixture was neutralized using diluted HCl. The residue was filtered off to afford the pure compound, which had a melting point of 250.3 – 253.9 C.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Cyano-N-(4-fluorophenyl)acetamide, and friends who are interested can also refer to it.
Reference:
Patent; GEORGETOWN UNIVERSITY; ALKEM LABORATORIES LIMITED; PADMANABHAN, Radhakrishnan; NAGARAJAN, Kuppuswamy; RAO, Kothapalli Sundarraja; SHRIDHARA, Kanakamajalu; SHASHIPRABHA, .; HARISHA, Attimogae Shivamurthy; WO2014/164667; (2014); A1;,
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