Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33143-29-2, name is 2,2-Dimethyl-2H-chromene-6-carbonitrile, A new synthetic method of this compound is introduced below., name: 2,2-Dimethyl-2H-chromene-6-carbonitrile
To a stirred cooled solution of 2,2-dimethyl-6-cyano-2H-benzo[b]pyran (6.56 g) in dimethyl sulphoxide (65 ml) and water (1.30 ml) was added freshly crystallized N-bromosuccinimide (12.63 g) in one portion. Dilution with water after stirring for an additional 1 hour, and insolation via ethyl acetate gave trans-3-bromo-3,4-dihydro-2,2-dimethyl-6-cyano-2H-benzo[b]pyran-4-ol as a white crystalline solid (10.54 g), a small portion of which recrystallized from 60-80 petroleum ether had m.p. 128-128.5 C.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Beecham Group Limited; US4251537; (1981); A;,
Nitrile – Wikipedia,
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