Synthetic Route of 3544-25-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3544-25-0, name is 2-(4-Aminophenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
1. 4-Hydrazinobenzylcyanide. Hydrochloride A solution of NaNO2 (80 g, 1.16 mol) was added dropwise to a cooled (-10 C.), stirred, suspension of 4-aminobenzyl cyanide (153.5 g, 1.16 mol) in concentrated HCl (1500 ml), at such a rate that the temperature did not rise above -10 C. The mixture was stirred at -10 C. for 0.25 h before being filtered rapidly under vacuum into an addition funnel. The solution was added portionwise over a 0.25 h period to a rapidly stirred mixture of SnCl2.2H2 O (1.05 kg, 4.64 mol) in concentrated HCl (800 ml) keeping the temperature below -5 C. The mixture was allowed to warm to room temperature and stir for 0.25 h before filtering the sandy coloured precipitate under vacuum and washing with ether (5*500 ml). The resultant solid was dried over P2 O5 in a vacuum oven (80 C.) for 16 h to give the title compound (213 g, 100%), m.p. 181-183 C.; 1 H NMR (360 MHz, D2 O) delta 3.90 (2H, s, CH2); 7.06 (2H, d, J=8.7 Hz, Ar-H); 7.40 (2H, d, J=8.7 Hz, Ar-H).
The synthetic route of 2-(4-Aminophenyl)acetonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck Sharp & Dohme Limited; US5298520; (1994); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts