Electric Literature of 79463-77-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 79463-77-7, name is Diphenyl N-cyanocarbonimidate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Alternatively, a mixture of 2n (4.46 g, 21.3 mmol) and diphenylcyanocarbimidate (5.07 g, 21.3 mmol) in 2-PrOH (100 mL) was stirred at ambient temperature under N2 for 20 h. The solids that formed were collected by filtration and washed with 2-PrOH to afford 3k (5.90 g, 78%) as an off-white solid: 1H NMR (300 MHz, DMSO-d6) delta 10.82 (s, 1 H), 7.50-7.37 (m, 2H), 7.32-7.26 (m, 4H), 7.08-7.03 (m, 2H), 6.82 (dd, J = 7.9, 1.9 Hz, 1H), 4.98 (t, J = 4.9 Hz, 1 H), 4.07 (t, J = 6.5 Hz, 2H), 3.93-3.76 (m, 4H), 2.06-2.00 (m, 2H).
The synthetic route of Diphenyl N-cyanocarbonimidate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RIGEL PHARMACEUTICALS, INC.; WO2007/30680; (2007); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts