Share a compound : 3218-45-9

Electric Literature of 3218-45-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3218-45-9 name is 2-(2,3-Dichlorophenyl)acetonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a suspension of 2,3-dichiorophenyiacetonitriie {45 kg, 241 .9 mole) in methanol litres) was charged 30% w/w sodium methoxide in methanol solution ( 1 13.5 kg, 630.6 mole) then ethyifluoroacetate (29.7 kg, 280.1 mole). The reaction mixture was stirred overni¡ãhi and the product was precipitated from aqueous hydrochloric acid (63.7 kg, 648 mole) in water (350 litres). The slurry was filtered and the solid was dissolved in ethyl acetate and washed with brine solution. Ethyl acetate (100 litres) was removed by vacuum distillation. DMF (70 litres) was added and the distillation continued to remove the remaining ethyl acetate.To the resulting enol in DMF was added potassium carbonate (20 kg. 145 mole) over a period of 10 minutes. Aikyiation of the potassium enoiale was achieved using ethyl iodide (37.7kg, 24^ .9 mole) at 70’C for VA hours. The reaction mixture was partitioned between toluene (140 litres) and water (75 litres) and the toluene chase was washed with water (50 litres). Toluene (75 iitres) was removed by distillation to afford the crude product as a toluene solution.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2,3-Dichlorophenyl)acetonitrile, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2007/93587; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts