Application of 33143-29-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33143-29-2, name is 2,2-Dimethyl-2H-chromene-6-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: PICP-n (4 mol%, based on Mn ion content in PICP-n), unfunction-alized alkenes (0.5 mmol) and pyridine N-oxide (0.095 g, 1 mmol)were added into dichloromethane (2 ml) under stirring. Buffered NaClO (1 mmol, pH = 11.5) as an oxidant was then added in four equal portions at 0C. The progress of epoxidation was moni-tored by GC. After the reaction, volatile solvents were evaporatedunder in a vacuum. PICP-n was precipitated out from reaction system by the addition of n-hexane (5 ml), washed withether (3 ¡Á 5 ml), dried in vacuum, and finally recharged withfresh solvents and reaction substrates for the next catalytic cycle.Supernatant was decanted and separated by separatory funnel.Aqueous phase was extracted with CH2Cl2for several times. Theextract was combined with organic phase. The collected organicphase was dried over anhydrous sodium sulfate and concen-trated in vacuum. Further purification of the residue by flashcolumn chromatography afforded pure epoxides. The conversionsand ee values were measured by a 6890 N gas chromatograph(Agilent Co.) equipped with a chiral capillary column (HP19091G-B213, 30 m ¡Á 0.32 mm ¡Á 0.25 m) and a FID detector. Nitrogenwas used as the carrier gas with a flow of 30 ml min-1. The injector temperature is 250C, and the detector temperatureis also 250C. The retention times of the corresponding chiralepoxides (tabsolute configuration) are as follows: (a) styrene epox-ide: the column temperature is 90C, tR= 15.2 min, tS= 15.7 min;(b) -methylstyrene epoxide: the column temperature is 80C,tS= 16.3 min, tR= 16.5 min; (c) indene epoxide: the column tem-perature was programmed from 80 to 180C with 8C min-1,tSR= 11.5 min, tRS= 11.9 min; (d) 1,2-dihydronaphthalene epox-ide: the column temperature was programmed from 80 to180C with 6C min-1, tSR= 13.4 min, tRS= 13.6 min; (e) 6-cyano-2,2-dimethylchromene epoxide: the column temperature wasprogrammed from 80 to 200C with 4C min-1, tSS= 24.0 min,tRR= 24.3 min; (f) 6-nitro-2,2-dimethylchromene epoxide: the col-umn temperature was programmed from 80 to 200C with 4C min-1and retained at 200C for 5 min, tSS= 30.3 min,tRR= 30.8 min.
The chemical industry reduces the impact on the environment during synthesis 2,2-Dimethyl-2H-chromene-6-carbonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Article; Chen, Yaju; Tan, Rong; Zhang, Yaoyao; Zhao, Guangwu; Zheng, Weiguo; Luo, Rongchang; Yin, Donghong; Applied Catalysis A: General; vol. 491; 1; (2015); p. 106 – 115;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts