In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51762-67-5, name is 3-Nitrophthalonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H3N3O2
3-(2,4-Dimethyl-3-pentyloxy)phthalonitrile (1) was preparedas described previously with some modifications [41].Sodium hydride (1.92 g, 48 mmol, 60% dispersion in mineraloil) was added portion-wise to a cooled DMF (30 mL, 0 C)under argon, and then 2,4-dimethyl-3-pentanol (4.53 g, 39mmol) was added drop-wise, followed by stirring for 1 h. Asolution of 3-nitrophthalonitrile (5.19 g, 30 mmol) in DMF(10 mL) was added slowly to the above solution over 1 h. The resulting solution was warmed to room temperature, andstirred for 1 h. After the reaction, the reaction mixture waspoured into water (500 mL) and stirred for 1 h. The solidformed was recovered by filtration and washed with water(50 mL¡Á3). This crude product was purified by columnchromatography on silica gel using CHCl3 as eluent to givea white solid (4.83 g, 66% yield). 1H NMR (CDCl3, 500MHz): 0.95 (d, 6H), 1.01 (d, 6H), 2.13 (m, 2H), 4.05 (t, 1H),7.26 (d, 1H), 7.28(d, 1H), 7.57 (t, 1H).
The synthetic route of 51762-67-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jiang, Xiaoqing; Yu, Ze; Lai, Jianbo; Zhang, Yuchen; Lei, Ning; Wang, Dongping; Sun, Licheng; Science China Chemistry; vol. 60; 3; (2017); p. 423 – 430;,
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