Reference of 2042-37-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2042-37-7, name is 2-Bromobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
To a stirred solution of 213 mg (1 mmol) Int1.2 in THF (2.5 mL) was added 364 mg (2 mmol, 2 eq) 2-Brombenzonitril, 183 mg (0.2 mmol, 0.2 eq) Pd2(dba)3, 374 mg (0.6 mmol, 0.6 eq) rac-BINAP and 240 mg (2.5 mmol, 2.5 eq) NaOtBu at room temperature in a microwave reactor. The solution was heated at 150 C for 50 min under microwave irradiation. After cooling, the solution was filtered and evaporated. Subsequent purification by by preparative reverse phase HPLC gave 186 mg (59 %) of the title compound. 1H-NMR (300 MHz, d6-DMSO): delta = 9.56 (1H, s), 9.16 (1H, s), 7.91 (1H, d), 7.72 (1 H, d), 7.70 (1 H, d), 7.62 (1 H, dd) 7.54 (1 H, d), 7.15 (1 H, dd) ppm. UPLC-MS: RT = 1.15 min; m/z (ES+) 315.2 [MH+]; required MW = 314.2.
The chemical industry reduces the impact on the environment during synthesis 2-Bromobenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Bayer Schering Pharma AG; EP2343297; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts