Reference of 875664-25-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 875664-25-8, name is 4-Bromo-2-phenoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
Compound 5c (35.3 g, 129 mmol) was added to 130 mL EtOH, followed by the addition of 340 ml_ of 20% aqueous NaOH. The reaction was heated to reflux for 20 h. At that time the mixture was cooled to room temperature and poured into 6 N HCI. The solid was collected by vacuum filtration, dissolved in 3:1 THF-ethyl ether, and washed with brine. The organic phase was dried (MgSO4) and concentrated. The solids were dried in a vacuum oven at 60C overnight to give the desired compound 1b. MS m/z (MH+) 292.
The chemical industry reduces the impact on the environment during synthesis 4-Bromo-2-phenoxybenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/30089; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts