Related Products of 33143-29-2,Some common heterocyclic compound, 33143-29-2, name is 2,2-Dimethyl-2H-chromene-6-carbonitrile, molecular formula is C12H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Enantioselective epoxidation reactions were performed with catalyst 1 (0.02 mmol) using styrene (STY), cis beta-methyl styrene (MSTY), indene (IND), 2,2-dimethylchromene (CHR), 6-cyano-2,2-dimethylchromene (CN-CHR), 6-methoxy-2,2-dimethylchromene (MeO-CHR), spiro[cyclohexane-1,2-[2H][1]chromene] (Cy-CHR) (1 mmol) as substrates in dichloromethane (3 mL) in the presence of PyNO (0.13 mmol) as an axial base with aqueous buffered NaOCl (12%, 2.75 mmol; pH=11.3) as an oxidant. The NaOCl was added in five equal portions at 0 C, and the reaction mass was stirred using a mechanical stirrer at 900+/-20 rpm. The course of the epoxidation reaction was monitored by GC with n-tridecane (0.1 mmol) as a GLC internal standard for product quantification. After completion of the reaction, the immobilized catalyst 1 was separated by centrifugation, washed thoroughly with dichloromethane, and dried in vacuum for subsequent catalytic runs.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,2-Dimethyl-2H-chromene-6-carbonitrile, its application will become more common.
Reference:
Article; Roy, Tamal; Kureshy, Rukhsana I.; Khan, Noor-Ul H.; Abdi, Sayed H.R.; Sadhukhan, Arghya; Bajaj, Hari C.; Tetrahedron; vol. 68; 31; (2012); p. 6314 – 6322;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts