Adding a certain compound to certain chemical reactions, such as: 31643-49-9, name is 4-Nitrophthalonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31643-49-9, category: nitriles-buliding-blocks
Mixture of 4-Hydroxybenzaldehyde 1 (0.122g, 1 mmol), 4-Nitrophthalonitrile 2 (0.173 g, 1 mmol) and K2CO3 (0.138 g, 1 mmol) were dissolved in 2 mL DMF. The mixture was stirred at room temperature for 24 h. After completion of the reaction, 1 mL acetone and 5 mL water was added respectively to the reaction mixture, the resulting precipitates were separated and washed with 10 ml hot water and 10 ml hot ethanol.
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Reference:
Article; Karimi, Ali Reza; Khodadadi, Azam; Tetrahedron Letters; vol. 53; 39; (2012); p. 5223 – 5226;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts