Electric Literature of 31643-49-9, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 31643-49-9, Name is 4-Nitrophthalonitrile, SMILES is C1=C(C(=CC=C1[N+](=O)[O-])C#N)C#N, belongs to nitriles-buliding-blocks compound. In a article, author is Nadaf, AfraQuasar A., introduce new discover of the category.
Synthesis of 1,2-Disubstituted Imidazole Derivatives as Potent Inhibitors of Mycobacterium tuberculosis and Their In Silico Studies
A multi-step synthetic protocol was employed to accomplish the synthesis of (2Z)-2-((E)-4-(benzylideneamino)phenyl)-3-(1-methyl-1H-imidazol-2-yl)acrylonitrile derivatives. The title compounds were screened for antitubercular activity. Amongst them, three of the compounds appeared promising with a MIC value 0.2 to 0.4 mu g/mL whereas the other compounds have also exhibited lower MIC than the standards. Docking study was performed to check their binding interaction and to deduce the possible mechanism of action involved in the inhibition process which revealed that the newly synthesized molecules act by inhibiting the DprE1 enzymatic pathway.
Electric Literature of 31643-49-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 31643-49-9.