Month: March 2021

Related Products of 51762-67-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51762-67-5, name is 3-Nitrophthalonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(. 3. 18 g, 21 17 mmol), anhydrous potassium carbonate (. 15.20 g, 0 11 mol) was added to the IJ IOOml round-bottomed flask, dissolved in acetonitrile and heated to 90 C under nitrogen; 3- nitro-phthalonitrile (. 1.83 g, 10 58 mmol) dissolved in acetonitrile after transfer to constant pressure dropping funnel and slowly added dropwise to the flask, continued after the addition was complete the reaction at 90 C at 18 h; After completion of the reaction, acetonitrile was removed by rotary evaporation under reduced pressure, the residue was extracted with methylene chloride; the resulting crude product with dichloromethane – methanol 30: 1 (v / v) as eluent, separated by silica gel column chromatography to give a pale after yellow oily liquid Technology Xhttp://www.technology-x.net/A61K/201410486382_2.html

The synthetic route of 3-Nitrophthalonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fuzhou University; Liu, Jianyong; Ye, Farong; Lu, Yuan; (24 pag.)CN104311566; (2016); B;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 41171-91-9 as follows. Product Details of 41171-91-9

To the solution of 3-cyanocyclopentanone prepared above (91.6 g) in MeOH (1300 ml) was added NaBH4 (32.0 g) in portions while maintaining the temperature between 20- 30 C. After the addition was completed the mixture was stirred at rt for 30min. The mixture was evaporated and purification of the residue by column chromatography on silica gel (50 % petroleum ether/EtOAc) afforded 3-Hydroxy-cyclopentanecarbonitrile (62.0 g) as a colorless oil. T

According to the analysis of related databases, 41171-91-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BERGERON, Philippe; BODIL VAN NIEL, Monique; DRAGOVICH, Peter; HURLEY, Christopher; KULAGOWSKI, Janusz; LABADIE, Sharada; MCLEAN, Neville James; MENDONCA, Rohan; PULK, Rebecca; ZAK, Mark; WO2013/7765; (2013); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 499983-13-0, name is 4-Bromo-3-fluorophenylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-Bromo-3-fluorophenylacetonitrile

To a solution of compound A26-3 (9.6 g, 45 mmol) in THF (100 ml) under N2 at room temperature was added LDA (2M inTHF, 56 ml) over 1 h. Then the mixture was treated with iodomethane (22. 3g, 157.5 mmol). The mixture was then quenched by adding H20 (50 mL) and extracted with EtOAc (100 mL) three times. The combined organic layers were washed with brine, dried over Na2504, and concentrated in vacuo to provide a residue, which was purified by chromatography over silica gel (eluting with PE: EA=10: 1) to give compound A26-4.

According to the analysis of related databases, 499983-13-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BIFU, Tesfaye; BIJU, Purakkattle; BLIZZARD, Timothy A.; CHEN, Zhengxia; CLEMENTS, Matthew J.; CUI, Mingxiang; FRIE, Jessica L.; HAGMANN, William K.; HU, Bin; JOSIEN, Hubert; NAIR, Anilkumar G.; PLUMMER, Christopher W.; WO2015/176267; (2015); A1;,
Nitrile – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 5724-56-1, name is 2,3-Dimethylbenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5724-56-1, Safety of 2,3-Dimethylbenzonitrile

Description 1: 2,3-Bis(bromomethyl)benzonitrile. A mixture of 2,3-dimethylbenzonitrile (available from Fluorochem, 5g, 38.1 mmol), N- bromosuccinimide (13.6g, 76.2mmol) and benzoyl peroxide (460mg, 1.9mmol) in carbon tetrachloride (270ml) was stirred and heated at 800C for 20 hours then cooled and washed with 4x60ml of water. The organic phase was dried (magnesium sulphate), evaporated and purified by flash chromatography eluting with ethyl acetate/iso-hexane (1 :9) to give a yellow solid which was 58% pure by LC/MS. 1H NMR (CDCI3) delta : 4.63 (2H, s), 4.82 (2H, s), 7.43 (1 H, t), 7.64 (2H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Dimethylbenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/80729; (2009); A1;,
Nitrile – Wikipedia,
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Reference of 119584-73-5, The chemical industry reduces the impact on the environment during synthesis 119584-73-5, name is 2-Ethoxy-6-fluorobenzonitrile, I believe this compound will play a more active role in future production and life.

To a solution of 2-ethoxy-6-fluorobenzonitrile (2.00 g, 12.1 mmol, 1 eq) in ethanol (30 mL) was added hydrazine hydrate (0.884 mL, 18.1 mmol, 1.5 eq) at RT. The mixture was heated to 70 C. for 30 h. After cooling to RT, water (20 mL) was added, the mixture was extracted with ethyl acetate (2*50 mL), the combined organic phases were washed with brine (50 mL), dried over MgSO4, filtered and evaporated in vacuo. The residue was triturated with MTBE (10 mL), filtered and the residue was dried for 16 h at 50 C. in vacuo to yield the title compound 4-ethoxy-1H-indazol-3-amine (1.01 g, 47% of theory).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Ethoxy-6-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; Hassfeld, Jorma; KINZEL, Tom; Koebberling, Johannes; CANCHO GRANDE, Yolanda; BEYER, Kristin; Roehrig, Susanne; Koellnberger, Maria; SPERZEL, Michael; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; ELLERMANN, Manuel; US2015/126449; (2015); A1;,
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52798-01-3, name is Methyl (4-cyanophenyl)acetate, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of Methyl (4-cyanophenyl)acetate

a) To a solution of methyl (4-cyanophenyl)acetate (4.00 g, 27.8 mmol) in MeOH (20 ml_), hydroxylamine hydrochloride (3.17 g, 45.7 mmol) and NaHCO3 (3.84 g, 45.7 mmol) is added. The suspension is stirred at 600C for 18 h before it is filtered and the filtrate is concentrated. The residue is dissolved in DCM, washed with water followed by brine, dried over MgSO4, filtered, concentrated and dried to give methyl [4-(N-hydroxycarbamimidoyl)- phenyl]-acetate (3.67 g) as a colourless oil; LC-MS: tR = 0.50 min, [M+1]+ = 209.05.

The synthetic route of 52798-01-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/29370; (2008); A1;,
Nitrile – Wikipedia,
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Application of 403-54-3, A common heterocyclic compound, 403-54-3, name is 3-Fluorobenzonitrile, molecular formula is C7H4FN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 3-fluorobenzonitrile (70; 20.0 g, 165 mmol) and EtOH (50 m L) and was cooled with an ice-bath. HC1 gas was bubbled through the solution unti l saturation and the reaction mixture was stirred overnight. The solid was col lected by filtration and was washed with cold ether to obtain ethyl-3-fluorobenzimidate hydrochloride as a solid (71 ; 33.5 g, 99% yield). MS (ESI) calcd for C9H,0FNO-HC1: 203.64.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; NG, Pui, Yee; BLUM, Charles; MCPHERSON, Lauren; PERNI, Robert, B.; VU, Chi, B.; AHMED, Mohammed, Mahmood; DISCH, Jeremy, S.; WO2011/59839; (2011); A1;,
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Electric Literature of 7251-09-4,Some common heterocyclic compound, 7251-09-4, name is 4-Amino-2-methoxybenzonitrile, molecular formula is C8H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of an aldehyde (1.0 eq) and an amine (1.0 eq) was heated in a sealed tube at 60 C for 6 h. The crude material was dried under vacuum over phosphorus(V) oxide to give quantitatively the imine which was used in the next step without further purification.

The synthetic route of 7251-09-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; BARDIOT, Dorothee; CARLENS, Gunter; DALLMEIER, Kai; KAPTEIN, Suzanne; McNAUGHTON, Michael; MARCHAND, Arnaud; NEYTS, Johan; SMETS, Wim; WO2013/45516; (2013); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 622-75-3, name is 2,2′-(1,4-Phenylene)diacetonitrile, A new synthetic method of this compound is introduced below., Product Details of 622-75-3

Weigh 1,4-benzenediacetonitrile 0.807 g (5.17 mmoL) was dissolved in 20 mL of ethanol,Add NaOH for 0.5h,Weigh the first step of the product 3g (10.3mmoL) into the flask after 3h reaction,The reaction solution was washed with saturated brine and dried over anhydrous sodium sulfate,After filtration, the solvent was removed by distillation under reduced pressure to give 2.60 g of a pale yellow solid;

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Hefei University of Technology; LU, HONG BO; ZHANG, SHAN NA; YANG, JIA XIANG; LU, GUO QIANG; QIU, LONG ZHEN; ZHANG, GUI YU; XU, WEI; (11 pag.)CN103641742; (2016); B;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 218632-01-0, name is 3-Fluoro-4-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., name: 3-Fluoro-4-nitrobenzonitrile

To a stirred solution of 3-fluoro-4-nitrobenzonitrile (2 g, 12.05 mmol) in CH2C12 (250 mE) under an inert atmosphere was added potassium carbonate (3.32 g, 24.09 mmol) and ethylamine (Aq. 70%, 2.17 g, 48.19 mmol) at room temperature. The reaction mixture was stirred at room temperature for 6 h. Afier consumption of starting material (by TEC), the reaction mixture was quenched with water (60 mE) and extracted with EtOAc (2×60 mE). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford 3 -(ethylamino)-4-nitrobenzonitrile (1.9 g, crude) as yellow solid used in next step without thrther purification. ?H NMR (500 MHz, DMSO-d5): oe 8.22-8.10 (m, 2H), 7.58 (br s, 1H), 7.00 (br d, J=8.7 Hz, 1H), 3.48-3.38 (m, 2H), 1.21 (br t, J=6.9 Hz, 3H). EC-MS: m/z 192.1 [M+H] at 4.10 RT (98.96% purity).

According to the analysis of related databases, 218632-01-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Viamet Pharmaceuticals (NC), Inc.; Sparks, Steven; Yates, Christopher M.; Shaver, Sammy R.; Hoekstra, William J.; (156 pag.)US2018/185362; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts