Month: March 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 145689-34-5, name is 2-(2,3-Difluorophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 145689-34-5

Example 1.2 (6S .V (6?8.S)-6-(2,3-Difluo^ <3]pyridin-8-yl]-2l-oxo 25j etrahy ft]pyr idine] -3 -carb xamide Step A: Methyl 2-[(feA-f-butoxycarbonyl)aminol-4-cyano-4-(2,3-difluorophenyl)butanoate To a solution of (2,3-difluorophenyl)acetonitrile (18.6 g, 122 mmol) ?eta Nu,Nu- dimethylformamide (243 mL) at 0 C was added sodium hydride (60% dispersion in mineral oil) (4.37 g, 109 mmol). After 20 min, methyl N~(tert~butoxycarbonyl)~3~iodo-Z)-alaninate (20.0 g, 60.8 mmol) was added, and the resulting mixture stirred 50 min. Saturated aqueous sodium bicarbonate was added, and the mixture was warmed to ambient temperature. Water was added and the mixture was extracted with ethyl acetate (3 ). The combined organic extracts were washed with water (3x), brine, dried over magnesium sulfate, filtered and concentrated. Purification by silica gel chromatography (100% hexanes? 20% hexanes/ ethyl acetate) gave the title compound (12.0 g). MS 377.3 (M+Na), Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 145689-34-5. Reference:
Patent; MERCK SHARP & DOHME CORP.; BURGEY, Christopher, S.; GINNETTI, Anthony; NOMLAND, Ashley; PAONE, Daniel, V.; WO2013/66360; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 1250444-23-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1250444-23-5, name is 3-Bromo-2,6-difluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

3-bromo-2,6-difluorobenzonitrile and triethyl phosphite were fed at a ratio of 1: 8.0, N2 was protected, reacted The temperature is 100 C and the reaction is carried out under light conditions. TLC was monitored and reacted for 30 h until the feed point disappeared. The product is decompressed Distillation, the oil bath temperature to 10 C, steaming low boiling point fraction. The product was again subjected to vacuum distillation at an oil bath temperature of 190 C and steamed A high boiling fraction is taken and the fraction is taken at a temperature of 135-145 C. The distillate is dissolved in ethyl acetate and treated with 10% Na2C03, saturated sodium chloride, washed with anhydrous magnesium sulfate, filtered and evaporated to give a yellow oily liquid product in 83% yield.

The chemical industry reduces the impact on the environment during synthesis 3-Bromo-2,6-difluorobenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Tianjin Normal University; Song, fanbo; Zhang, ZhongBiao; Li, huayun; Tang, hongying; Wang, ZhiJiang; Song, AiRu; (8 pag.)CN104017021; (2016); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7357-70-2, name is 2-Cyanothioacetamide, A new synthetic method of this compound is introduced below., SDS of cas: 7357-70-2

12.46 g (75 mmol) of 4-(2-hydroxyethoxy)benzaldehyde, 15.02 g (150 mmol) of cyanothioacetamide and 15.15 g (150 mmol) of N-methylmorpholine are initially charged in 75 ml of ethanol and heated under reflux for 3 h. After cooling, the reaction solution is concentrated under reduced pressure. The residue is dissolved in IN aqueous sodium hydroxide solution and washed twice with ethyl acetate. The aqueous sodium hydroxide phase is acidified with IN hydrochloric acid and the precipitated crystals are filtered off with suction and dried under reduced pressure at 450C. This gives 12.05 g (51% of theory) of product.MS (ESIpos): m/z = 313 (M+H)+, 330 (M+NH^1H=NMR (300 MHz, DMSO-d*): delta = 3.7 (t, 2H); 4.1 (t, 2H); 7.1 (d, 2H); 7.4 (d, 2H); 8.0 (br s, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BAYER HEALTHCARE AG; WO2007/73855; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 101184-73-0, The chemical industry reduces the impact on the environment during synthesis 101184-73-0, name is 2-(4-Bromophenyl)-2-methylpropanenitrile, I believe this compound will play a more active role in future production and life.

Reference Example 30b 2,2-Dimethyl-(4-[Furan-2-yl]-Phenyl)-Acetonitrile. Using essentially the same procedure as in reference example 30a, except using 2-(4-Bromo-phenyl)-2-methyl-propionitrile (reference example 31b). 1H NMR (CDCl3) d 1.74 (s, 6H), 6.47 (dd, J=2, 1 Hz, 1H), 6.66 (d, J=2 Hz, 1H), 7.47 (m, 3H), 7.68 (m, 2H),. MS (EI) m/z 211 (M)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Bromophenyl)-2-methylpropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Aventis Pharmaceuticals Inc.; US6541505; (2003); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25808-30-4, name is 2-(Methylamino)acetonitrile hydrochloride, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(Methylamino)acetonitrile hydrochloride

General procedure: A dry one neck 50mL round bottom flask equipped with magnetic stirring, reflux condenser, and nitrogen atmosphere (or drying tube) was charged with the vinamidinium salt (3.30 mmol), methylaminoacetonitrile hydrochloride (0.355 g, 3.33mmol) and triethylamine (0.97 mL, 6.95 mmol).Anhydrous acetonitrile (10 mL) was added and the mixture was allowed to stir at reflux overnight. The flask wascooled to room temperature and the volatiles were removed in vacuo. The remainingsolid was partitioned between water and ethyl acetate. The ethyl acetate layer was dried over sodiumsulfate and concentrated in vacuo togive the crude solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Smith, Stanton Q.; Dudek, Sean T.; He, Shu-Hui; Girod, Jarod A.; Nunes, Shane R.; Tetrahedron Letters; vol. 54; 30; (2013); p. 3965 – 3966;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 658-99-1, These common heterocyclic compound, 658-99-1, name is 2-(3,4-Difluorophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example S23; Preparation of 2-(3,4-difluoro-phenyl)-ethylamine hydrochloride; To 3.71 g of LiAlH4 (98 mmol) in 30 ml of dry diethylether were added dropwise at 0 C. under nitrogen 5 g of 3,4-difluoroacetonitrile (33 mmol) in 30 ml THF. After the addition and additional 15 min of stirring at 0 C., the ice bath was removed and the reaction was allowed to warm to ambient temperature. The flask was then immersed in an oil bath, heated to 55 C. and the reaction was refluxed overnight. The oil bath was then removed and the reaction mixture cooled to 0 C. The LiAlH4 was then quenched by the slow and sequential addition of saturated aqueous sodium sulfate solution. After the initial exothermic reaction had subsided, the flask was allowed to warm to ambient temperature and further sodium sulfate solution was added until the color was light grey. Then more solid sodium sulfate (dry) was added to dry the mixture, which was subsequently filtered through a short bed of sodium sulfate in a sinter funnel. To the filtrate was added a 5 N HCl solution in dioxane. The HCl-salt precipitated out and was filtered. The collected yellow solid (4.2 g; 82% yield) was found to be of good purity by NMR and was taken into the next step without further purification. MS (ISP) 158.1 (M+H)+.

The synthetic route of 658-99-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Conte-Mayweg, Aurelia; Kuehne, Holger; Luebbers, Thomas; Maugeais, Cyrille; Mueller, Werner; Pflieger, Philippe; US2006/30613; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 950596-58-4, name is 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile, A new synthetic method of this compound is introduced below., Computed Properties of C13H18N2O4

e) Synthesis of N’-[2-cyano-4, 5-bis (2-methoxyethoxy) phenyl]-N, N- dimethylformamidine:; _To a solution of DMF(12ml) and N,N-dimethylformamide dimethylacetal(DMA, 6ml, 0.045 moles) was added 2-amino-4,5-bis(2- methoxyethoxy)benzonitrile(6g, 0.0225moles) and refluxed for about 3hrs, concentrated excess DMF-DMA to obtain light brown liquid(6.5g)1HNMR (CDCI3): delta 3.06(s, 6H), 3.44(s, 6H), 3.75(m, 4H), 4.13(m, 4H), 6.48(s, ? 1 H), 7.02(s, 1H)1 7.55(s, 1 H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; VITTAL MALLYA SCIENTIFIC RESEARCH FOUNDATION; WO2007/138613; (2007); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 939-80-0, name is 4-Chloro-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 939-80-0, COA of Formula: C7H3ClN2O2

General procedure: To a solution of N-hydroxysalicylamide (0.5 g, 3.26 mmol) in anhydrous DMF (5 ml) was added 2a or 2b (3.26 mmol) and freshly calcinated K2CO3 (1.35 g, 9.78 mmol) and the mixture was kept, with stirring at the room temperature overnight. DMF was removed in vacuo and the residue was treated with water (10 ml) and then extracted with CH2Cl2 (5 ml). The organic layer was separated, washed with water, dried over anhydrous CaCl2, and purified by flesh chromatography on silica gel using CH2Cl2 as eluent. Dichloromethane was evaporated in vacuo. The resulting residue was benzo[d]oxazol-2(3H)-one 11. The water layer was acidify by hydrochloric acid, filtered and washed with water. The resulting residue was compound 12a(b).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-3-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sapegin, Alexander; Reutskaya, Elena; Smirnov, Alexey; Korsakov, Mikhail; Krasavin, Mikhail; Tetrahedron Letters; vol. 57; 52; (2016); p. 5877 – 5880;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 6393-40-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6393-40-4 name is 4-Amino-3-nitrobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Reduction of the nitro group with 10% Pd-C in Par hydrogenator afforded 2-amino-4-cyanoaniline in 85% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-3-nitrobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; University of North Carolina; US5428051; (1995); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 2469-99-0, These common heterocyclic compound, 2469-99-0, name is 3-Oxobutanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirring suspension of 5-hydrazinylisoquinoline (prepared from Example 25 step a, 0.60 g, 3.8 mmol) and 3-oxobutanenitrile (0.31 g, 3.8 mmol) in ethanol (3 mL) was heated at 80 C. for 2 h. After cooling to room temperature, the reaction mixture was in vacuo and the resulting crude residue was purified by flash chromatography (SiO2, 0-20% methanol in ethyl acetate) to give the desired product (0.067 g, 2.8 mmol, 73%).

The synthetic route of 2469-99-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHEMOCENTRYX, INC.; CHEN, Xi; FAN, Junfa; FAN, Pingchen; KRASINSKI, Antoni; LI, Lianfa; LUI, Rebecca M.; McMAHON, Jeffrey P.; POWERS, Jay P.; ZENG, Yibin; ZHANG, Penglie; US2013/225580; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts