Synthetic Route of 13338-63-1,Some common heterocyclic compound, 13338-63-1, name is 3,4,5-Trimethoxyphenylacetonitrile, molecular formula is C11H13NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: the aromatic carbaldehyde (1 mole) and the appropriate substituted phenylacetonitrile (1.1 mol equiv) were added to 5% sodium methoxide in methanol and the mixture was stirred at reflux temperaturefor 2-3 h. The resulting solid was filtered off, washed with water, and finally washed with cold methanol. The obtained crude solid was recrystallized from methanol to afford the desired product as a pure crystalline solid. The characterization data for the active compounds is given in reference section.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4,5-Trimethoxyphenylacetonitrile, its application will become more common.