Electric Literature of 6629-04-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6629-04-5 name is N-Cyanoacetylurethane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of B (25 g, 160 mmol), propionaldehyde (9.3 g, 160 mmol) and Sg (5.1 g, 160 mmol) in DMF (30 mL) at 0C under nitrogen was added morpholine (7.9 g, 90 mmol). Reaction mixture was heated at 50C for 30 min, monitored by TLC. Solvent was removed in vacuo, and the mixture poured into ice water (50ml), extracted with EtOAc, washed with water and brine and concentrated. Crude material was purified by column chromatography (silica gel, EtOAc:PE = 1 : 1) to give 5 (6.8g, 18%) as a yellow solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-Cyanoacetylurethane, and friends who are interested can also refer to it.